Pharmacokinetic parameters in swine after a single IM administration of EXCEDE FOR SWINE Sterile Suspension 100 mg/mL at 2.27 mg CE/lb (5.0 mg CE/kg) BWTable 2. Average plasma concentrations of ceftiofur- and desfuroylceftiofur-related metabolites for CCFA (EXCEDE FOR SWINE Sterile Suspension 100 mg/mL) after IM administration of 2.27 mg CE/lb (5.0 mg CE/kg) BW and those for ceftiofur sodium (NAXCEL Sterile Powder) after IM administration at 1.36 mg CE/lb (3 mg CE/kg) BW for three consecutive daysPharmacokinetic parameters measured after a single IM administration of 2.27 mg CE/lb (5.0 mg CE/kg) BW of EXCEDE FOR SWINE Sterile Suspension 100 mg/mL in the post-auricular region of the neck of swine are presented in the following table (Table 1).Table 1. No more than 2.0 mL should be injected in a single injection site. One animal had a visible lesion described as an area of tan with red speckles present in the deep muscle fascia, less than 6 cm2, at 10 days post-injection; this lesion and the remaining injection sites evaluated at 10 days post-injection were scored as “negative” for irritation.Table 4. Animal Healthcare Professionals. This is equivalent to 1.0 mL per 44 lbs (20 kg) body weight (BW). All rights reserved. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. Clinical observations were performed on Days 1-7 and rectal temperatures were taken on Days 1, 3, and 6 following treatment (Day 0). This makes … Repeated or prolonged exposure may lead to sensitization. Each ml of Excede for Swine contains ceftiofur crystalline free acid equivalent to 100 mg ceftiofur. Remove contaminated clothing. DESCRIPTION EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is a ready-to-use formulation that contains the crystalline free acid of ceftiofur, which is a broad spectrum cephalosporin antibiotic active against gram-positive and gram-negative bacteria including ß … Success was defined as a pig that survived to Day 7 and had normal attitude, normal respiration, and a rectal temperature of < 104 °F. No range; all isolates yielded the same value.The minimum inhibitory concentrations (MICs) of ceftiofur against indicated SRD pathogens were determined using methods recommended by the Clinical and Laboratory Standards Institute (CLSI) using the M31-A and M31-A3 standards for the SRD treatment (2000-2001) and control (2009) studies, respectively. *MIC for 90 percent of the isolates.EXCEDE is the only single dose injectable antibiotic approved for swine that delivers at least 7 days of therapeutic plasma levels with one injectionThe figure below shows the plasma profile for a single intramuscular injection (IM) dose of 5.0 mg/kg EXCEDE for Swine compared with three consecutive daily IM doses of 3.0 mg/kg of NAXCELEXCEDE is a prescription product. DESCRIPTION EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is a ready-to-use formulation that contains the crystalline free acid of ceftiofur, which is a broad spectrum cephalosporin antibiotic active against gram-positive and gram-negative bacteria including ß-lactamase-producing strains. Clinical observations were made daily. CLSI-accepted interpretive criteria for ceftiofur against swine respiratory disease pathogens** These interpretive criteria should only be used when the CLSI M31-A3 performance standard is used to determine antimicrobial susceptibility to ceftiofur.The effectiveness of a single dose of 2.27 or 3.18 mg CE/lb BW (5.0 or 7.0 mg CE/kg BW) EXCEDE FOR SWINE Sterile Suspension 100 mg/mL for the treatment of SRD was confirmed in a well-controlled, multi-location field study. All gross observations and measurements of injection sites qualified the sites at 10 days post-injection as “negative” for irritation.No adverse effects were observed in multi-location field efficacy studies involving more than 1000 pigs.Ceftiofur administered as either ceftiofur sodium (NAXCEL* Minimum inhibitory concentration for 90% of the isolatesThe average plasma concentrations of ceftiofur- and desfuroylceftiofur-related metabolites for CCFA (EXCEDE FOR SWINE Sterile Suspension 100 mg/mL) after IM administration of 2.27 mg CE/lb (5.0 mg CE/kg) BW and those for ceftiofur sodium (NAXCEL Sterile Powder) after IM administration at 1.36 mg CE/lb (3 mg CE/kg) BW for three consecutive days are presented in Figure 2 below.Figure 2.
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